Compound Detail
CHEMBL194113
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Basic Information
| ChEMBL ID | CHEMBL194113 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WTSNQZLKTLSHSD-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
266.3
MW (Da)
3.58
ALogP
4
HBA
2
HBD
58.3
PSA (Ų)
0.76
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.3 | 6.3 | 500.0 | 1 |
| Vascular endothelial growth factor receptor CHEMBL2095227 | IC50 | 5.78 | 5.78 | 1650.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 500.0 | nM | 6.3 | Inhibition of human Vascular endothelial growth factor receptor 2 | 15743202 |
| Vascular endothelial growth factor receptor | IC50 | = | 1650.0 | nM | 5.78 | Inhibition of VEGF-induced proliferation of human umbilical vein endothelial cel... | 15743202 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15743202 | 10.1021/jm049538w | Vascular endothelial growth factor receptor 2 | 1 |
| 15743202 | 10.1021/jm049538w | Vascular endothelial growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine