Assay Detail
Binding
CHEMBL829592
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Inhibition of human Vascular endothelial growth factor receptor 2
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.96 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 8.05 |
| CHEMBL194939 | — | — | 1 | 7.82 |
| CHEMBL193609 | — | — | 1 | 7.80 |
| CHEMBL190872 | — | — | 1 | 7.75 |
| CHEMBL178507 | — | — | 1 | 7.66 |
| CHEMBL194176 | — | — | 1 | 7.66 |
| CHEMBL275473 | GW572401X | — | 1 | 7.64 |
| CHEMBL365815 | — | — | 1 | 7.60 |
| CHEMBL193955 | — | — | 1 | 7.54 |
| CHEMBL191993 | — | — | 1 | 7.41 |
| CHEMBL369751 | — | — | 1 | 7.30 |
| CHEMBL370744 | — | — | 1 | 7.29 |
| CHEMBL193386 | — | — | 1 | 7.12 |
| CHEMBL195237 | — | — | 1 | 7.11 |
| CHEMBL194883 | — | — | 1 | 7.10 |
| CHEMBL364082 | — | — | 1 | 7.10 |
| CHEMBL364259 | — | — | 1 | 7.09 |
| CHEMBL191779 | — | — | 1 | 7.06 |
| CHEMBL372474 | GW678313X | — | 1 | 7.05 |
| CHEMBL191705 | GW621431X | — | 1 | 7.04 |
| CHEMBL179465 | GW621970X | — | 1 | 7.03 |
| CHEMBL443563 | GW627512B | — | 1 | 7.00 |
| CHEMBL361642 | — | — | 1 | 6.85 |
| CHEMBL1794060 | GW575533A | — | 1 | 6.85 |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 6.80 |
| CHEMBL176553 | GW631581B | — | 1 | 6.77 |
| CHEMBL179311 | GW580509X | — | 1 | 6.44 |
| CHEMBL179453 | GW622055X | — | 1 | 6.44 |
| CHEMBL1794062 | GW577921A | — | 1 | 6.42 |
| CHEMBL194062 | GW572399X | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24828 | VANDETANIB | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL194939 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL193609 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL190872 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL178507 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL194176 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL275473 | GW572401X | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL365815 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL193955 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL191993 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL369751 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL370744 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL193386 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL195237 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL364082 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL194883 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL364259 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL191779 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL372474 | GW678313X | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL191705 | GW621431X | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL179465 | GW621970X | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL443563 | GW627512B | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL361642 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL1794060 | GW575533A | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL101253 | VATALANIB | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL176553 | GW631581B | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL179311 | GW580509X | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL179453 | GW622055X | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1794062 | GW577921A | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL194062 | GW572399X | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL194113 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL371374 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL192417 | GW632046X | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL193912 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1794061 | GW627834A | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL318728 | GW549390X | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL191626 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL194117 | — | IC50 | > | 10000.0 | nM | - |