Compound Detail
CHEMBL318728
GW549390X Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL318728 |
| Name | GW549390X |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HFICAVMUTYFODG-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
236.3
MW (Da)
4.09
ALogP
3
HBA
1
HBD
38.1
PSA (Ų)
0.74
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.87
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.87 | 6.395 | 134.0 | 2 |
| Vascular endothelial growth factor receptor CHEMBL2095227 | IC50 | 5.52 | 5.52 | 3000.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 4.62 | 4.62 | 24000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 134.0 | nM | 6.87 | Inhibitory activity towards vascular endothelial growth factor receptor 2 | 15125964 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of human Vascular endothelial growth factor receptor 2 | 15743202 |
| Vascular endothelial growth factor receptor | IC50 | = | 3000.0 | nM | 5.52 | Inhibition of VEGF-induced proliferation of human umbilical vein endothelial cel... | 15743202 |
| NON-PROTEIN TARGET | IC50 | = | 24000.0 | nM | 4.62 | Inhibition of basic FGF-induced proliferation of human umbilical vein endothelia... | 15743202 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ABL1 | 14 |
| - | 10.6019/CHEMBL1961873 | Epidermal growth factor receptor | 10 |
| - | 10.6019/CHEMBL1961873 | Mast/stem cell growth factor receptor Kit | 8 |
| - | 10.6019/CHEMBL1961873 | Platelet-derived growth factor receptor alpha | 8 |
| - | 10.6019/CHEMBL1961873 | Proto-oncogene tyrosine-protein kinase receptor Ret | 6 |
| - | 10.6019/CHEMBL1961873 | Protein kinase C beta type | 4 |
| - | 10.6019/CHEMBL1961873 | Leucine-rich repeat serine/threonine-protein kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Cyclin-dependent kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Lyn | 4 |
| - | 10.6019/CHEMBL1961873 | Receptor-type tyrosine-protein kinase FLT3 | 4 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase B-raf | 4 |
| - | 10.6019/CHEMBL1961873 | Receptor tyrosine-protein kinase erbB-4 | 2 |
| - | 10.6019/CHEMBL1961873 | Macrophage colony-stimulating factor 1 receptor | 2 |
| - | 10.6019/CHEMBL2007661 | Serine/threonine-protein kinase TBK1 | 2 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Fes/Fps | 2 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Fer | 2 |
| - | 10.6019/CHEMBL1961873 | Receptor tyrosine-protein kinase erbB-2 | 2 |
| - | 10.6019/CHEMBL1961873 | Ephrin type-B receptor 4 | 2 |
| - | 10.6019/CHEMBL1961873 | Ephrin type-B receptor 3 | 2 |
| - | 10.6019/CHEMBL1961873 | Ephrin type-A receptor 3 | 2 |
Data from ChEMBL 36 via Core Engine