Assay Detail
Functional
CHEMBL832267
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Inhibition of basic FGF-induced proliferation of human umbilical vein endothelial cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Endothelial cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.27 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191993 | — | — | 1 | 5.96 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 5.92 |
| CHEMBL194176 | — | — | 1 | 5.24 |
| CHEMBL318728 | GW549390X | — | 1 | 4.62 |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191993 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL194176 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL318728 | GW549390X | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL101253 | VATALANIB | IC50 | = | 25000.0 | nM | 4.60 |