Compound Detail
CHEMBL1946430
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1946430 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SZIMUGUPXBFLOB-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
313.6
MW (Da)
5.83
ALogP
2
HBA
2
HBD
32.3
PSA (Ų)
0.31
QED
1
Ro5 Violations
18
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei gambiense CHEMBL613768 | EC50 | 6.35 | 6.35 | 451.0 | 1 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | EC50 | 6.23 | 6.23 | 584.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei gambiense | EC50 | = | 451.0 | nM | 6.35 | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei gambien... | 22119463 |
| Trypanosoma brucei rhodesiense | EC50 | = | 584.0 | nM | 6.23 | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei rhodesi... | 22119463 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22119463 | 10.1016/j.bmcl.2011.10.108 | Trypanosoma brucei rhodesiense | 2 |
| 22119463 | 10.1016/j.bmcl.2011.10.108 | Unchecked | 2 |
| 22119463 | 10.1016/j.bmcl.2011.10.108 | Trypanosoma brucei gambiense | 1 |
Data from ChEMBL 36 via Core Engine