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Compound Detail

CHEMBL1947155

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C[C@@H](NCc1ccccc1-c1ccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1)c1ccccc1

Basic Information

ChEMBL ID CHEMBL1947155
Phase Preclinical
Structure Type MOL
InChI Key XNZJTBRCBWPOTP-PBBNMVCDSA-N
1
Targets
2
Activities
2
Assay Types
2
PK Parameters
3
Publications
0
Known Names

Molecular Properties

539.7
MW (Da)
5.68
ALogP
6
HBA
5
HBD
97.4
PSA (Ų)
0.14
QED
2
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H33N3O3S
MW 539.70
Aromatic Rings 5
Heavy Atoms 39
NP-Likeness -0.33

Activity Summary

EC50 1 meas. best 8.4
IC50 1 meas. best 8.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
IC50 8.7 8.7 2.0 1
Beta-2 adrenergic receptor
CHEMBL210
EC50 8.4 8.4 4.0 1

Pharmacokinetic Data

Parameter Value Units Species
CL 104.5 mL.min-1.g-1 Homo sapiens
CL 108.0 uL.min-1.(10^6cells)-1 Rattus norvegicus

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22079756 10.1016/j.bmcl.2011.10.049 Beta-2 adrenergic receptor 3
- 10.6019/CHEMBL3301361 ADMET 2
- 10.6019/CHEMBL3301361 No relevant target 1

Data from ChEMBL 36 via Core Engine