Compound Detail
CHEMBL1949719
CYCLOLINOPEPTIDE A Enter ChEMBL ID:
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CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC1=O
Basic Information
| ChEMBL ID | CHEMBL1949719 |
| Name | CYCLOLINOPEPTIDE A |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | TTZALNKZCLGFGS-PUUGUDBISA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
1040.4
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.91
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bone marrow cell CHEMBL4296515 | IC50 | 4.91 | 4.91 | 12200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bone marrow cell | IC50 | = | 12200.0 | nM | 4.91 | Inhibition of RANKL-induced osteoclast differentiation in ICR mouse bone marrow ... | 26923696 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21839548 | 10.1016/j.ejmech.2011.07.040 | Splenocyte | 7 |
| 26923696 | 10.1016/j.bmcl.2016.02.040 | ADMET | 1 |
| 26923696 | 10.1016/j.bmcl.2016.02.040 | Bone marrow cell | 1 |
| 28662964 | 10.1016/j.bmc.2017.05.063 | HT-29 | 1 |
| 28662964 | 10.1016/j.bmc.2017.05.063 | A-431 | 1 |
Data from ChEMBL 36 via Core Engine