Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL197298

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(C(N)=O)cc1

Basic Information

ChEMBL ID CHEMBL197298
Phase Preclinical
Structure Type MOL
InChI Key PSTYCKJZBHYGPY-UBFVSLLYSA-N
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names

Molecular Properties

504.6
MW (Da)
2.51
ALogP
4
HBA
3
HBD
121.6
PSA (Ų)
0.51
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H36N4O4
MW 504.63
Aromatic Rings 2
Heavy Atoms 37
NP-Likeness -0.19

Activity Summary

Ki 1 meas. best 7.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Oxytocin receptor
CHEMBL2049
Ki 7.5 7.5 31.6 1

Pharmacokinetic Data

Parameter Value Units Species
AUC 44.0 ng.hr.mL-1 Rattus norvegicus

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Oxytocin receptor Ki = 31.62 nM 7.5 Displacement of [3H]oxytocin from human Oxytocin receptor 16250654

Literature References

PubMed DOI Target Context # Activities
16250654 10.1021/jm050557v Oxytocin receptor 1
16250654 10.1021/jm050557v ADMET 1
16250654 10.1021/jm050557v No relevant target 1

Data from ChEMBL 36 via Core Engine