Compound Detail
CHEMBL19742
TRANS-CPPA Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL19742 |
| Name | TRANS-CPPA |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SAFIVXBDNCNBIX-XINAWCOVSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
173.2
MW (Da)
-0.48
ALogP
3
HBA
3
HBD
86.6
PSA (Ų)
0.54
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | Ki | 6.3 | 6.3 | 500.0 | 1 |
| Glutamate receptor ionotropic, kainate CHEMBL2094119 | Ki | 5.8 | 5.8 | 1600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | Ki | = | 500.0 | nM | 6.3 | Compound was tested for the inhibition of [3H]L-Glutamate radioligand binding to... | - |
| Glutamate receptor ionotropic, kainate | Ki | = | 1600.0 | nM | 5.8 | Compound was tested for the inhibition of [3H]kainate radioligand binding to Ion... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23481645 | 10.1016/j.bmcl.2013.02.046 | Unchecked | 4 |
| - | 10.1016/S0960-894X(00)80103-1 | Excitatory amino acid transporter 2 | 2 |
| - | 10.1016/S0960-894X(96)00284-3 | Glutamate receptor ionotropic, kainate | 1 |
| - | 10.1016/S0960-894X(96)00284-3 | Glutamate receptor ionotropic, AMPA | 1 |
| - | 10.1016/S0960-894X(96)00284-3 | Glutamate NMDA receptor | 1 |
| - | 10.1016/S0960-894X(96)00284-3 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine