Compound Detail
CHEMBL197610
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Basic Information
| ChEMBL ID | CHEMBL197610 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QGAMUVOPYWEQSU-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
361.5
MW (Da)
4.72
ALogP
4
HBA
2
HBD
56.8
PSA (Ų)
0.47
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mast/stem cell growth factor receptor Kit CHEMBL1936 | IC50 | 6.6 | 6.12 | 250.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mast/stem cell growth factor receptor Kit | IC50 | = | 250.0 | nM | 6.6 | Inhibitory concentration against IL-3 independent Ba/F3 Kit cell line with SCF (... | 16190746 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 300.0 | nM | 6.52 | Inhibitory concentration against IL-3 independent Ba/F3 Kit D816V cell line | 16190746 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 1900.0 | nM | 5.72 | Inhibitory concentration against c-Kit D816V type expressed in recombinant bacul... | 16190746 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 2300.0 | nM | 5.64 | Inhibitory concentration against c-Kit wild type expressed in recombinant baculo... | 16190746 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16190746 | 10.1021/jm050231m | Mast/stem cell growth factor receptor Kit | 4 |
Data from ChEMBL 36 via Core Engine