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Compound Detail

CHEMBL1987798

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COc1ccc(/N=C/c2sc(O)c3ccccc23)cc1

Basic Information

ChEMBL ID CHEMBL1987798
Phase Preclinical
Structure Type MOL
InChI Key GDWUWJSIRSBEFA-LICLKQGHSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

283.4
MW (Da)
4.37
ALogP
4
HBA
1
HBD
41.8
PSA (Ų)
0.73
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H13NO2S
MW 283.35
Aromatic Rings 3
Heavy Atoms 20
NP-Likeness -0.76

Activity Summary

EC50 4 meas. best 6.64

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 6.64 6.5 228.0 3
Nuclear factor NF-kappa-B complex
CHEMBL2094258
EC50 6.0 6.0 992.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine