Compound Detail
CHEMBL199591
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CO[C@]1(C#CC(O)(c2cccc(C(F)(F)F)c2)c2cccc(C(F)(F)F)c2)CN2CCC1CC2
Basic Information
| ChEMBL ID | CHEMBL199591 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LTTDHGFPRZVXKM-JOCHJYFZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
483.4
MW (Da)
5.07
ALogP
3
HBA
1
HBD
32.7
PSA (Ų)
0.49
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 CHEMBL245 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 | Ki | = | 1000.0 | nM | 6.0 | Binding affinity to human muscarinic M3 receptor | 16275087 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16275087 | 10.1016/j.bmcl.2005.09.079 | Muscarinic acetylcholine receptor M3 | 1 |
| 16275087 | 10.1016/j.bmcl.2005.09.079 | Muscarinic acetylcholine receptor M2 | 1 |
Data from ChEMBL 36 via Core Engine