Assay Detail
Binding
CHEMBL863985
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Binding affinity to human muscarinic M3 receptor
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent anti-muscarinic activity in a novel series of quinuclidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 8.50 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370232 | — | — | 1 | 10.30 |
| CHEMBL200401 | — | — | 1 | 10.10 |
| CHEMBL381623 | — | — | 1 | 9.89 |
| CHEMBL200693 | — | — | 1 | 9.70 |
| CHEMBL200432 | — | — | 1 | 9.60 |
| CHEMBL200171 | — | — | 1 | 9.60 |
| CHEMBL427013 | — | — | 1 | 9.49 |
| CHEMBL200319 | — | — | 1 | 9.40 |
| CHEMBL200416 | — | — | 1 | 9.20 |
| CHEMBL382213 | — | — | 1 | 9.10 |
| CHEMBL383389 | — | — | 1 | 9.10 |
| CHEMBL203249 | — | — | 1 | 9.00 |
| CHEMBL200957 | — | — | 1 | 9.00 |
| CHEMBL381878 | — | — | 1 | 9.00 |
| CHEMBL1231 | OXYBUTYNIN | 4.0 | 1 | 8.89 |
| CHEMBL201933 | — | — | 1 | 8.89 |
| CHEMBL1346 | DARIFENACIN | 4.0 | 1 | 8.89 |
| CHEMBL199821 | — | — | 1 | 8.60 |
| CHEMBL371734 | — | — | 1 | 8.49 |
| CHEMBL1382 | TOLTERODINE | 4.0 | 1 | 8.49 |
| CHEMBL370862 | — | — | 1 | 8.40 |
| CHEMBL380583 | — | — | 1 | 8.10 |
| CHEMBL199981 | — | — | 1 | 8.10 |
| CHEMBL383248 | — | — | 1 | 8.10 |
| CHEMBL200210 | — | — | 1 | 8.00 |
| CHEMBL372566 | — | — | 1 | 7.89 |
| CHEMBL381020 | — | — | 1 | 7.70 |
| CHEMBL373256 | — | — | 1 | 7.40 |
| CHEMBL381469 | — | — | 1 | 7.30 |
| CHEMBL200208 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370232 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL200401 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL381623 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL200693 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL200432 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL200171 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL427013 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL200319 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL200416 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL382213 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL383389 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL203249 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL200957 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL381878 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1346 | DARIFENACIN | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL1231 | OXYBUTYNIN | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL201933 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL199821 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL371734 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL1382 | TOLTERODINE | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL370862 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL380583 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL199981 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL383248 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL200210 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL372566 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL381020 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL373256 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL381469 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL200208 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL200209 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL200566 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL197973 | — | Ki | = | 631.0 | nM | 6.20 |
| CHEMBL199591 | — | Ki | = | 1000.0 | nM | 6.00 |