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Compound Detail

CHEMBL380583

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CO[C@]1(C#CC(O)(c2cccc(C)c2)c2cccc(C)c2)CN2CCC1CC2

Basic Information

ChEMBL ID CHEMBL380583
Phase Preclinical
Structure Type MOL
InChI Key CGVBUQQTPXIKLP-XMMPIXPASA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

375.5
MW (Da)
3.65
ALogP
3
HBA
1
HBD
32.7
PSA (Ų)
0.83
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H29NO2
MW 375.51
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness 0.22

Activity Summary

Ki 2 meas. best 8.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M3
CHEMBL245
Ki 8.1 8.1 7.9 1
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 7.3 7.3 50.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16275087 10.1016/j.bmcl.2005.09.079 Muscarinic acetylcholine receptor M3 1
16275087 10.1016/j.bmcl.2005.09.079 Muscarinic acetylcholine receptor M2 1

Data from ChEMBL 36 via Core Engine