Assay Detail
Binding
CHEMBL863986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human muscarinic M2 receptor
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent anti-muscarinic activity in a novel series of quinuclidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.74 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370232 | — | — | 1 | 9.70 |
| CHEMBL200401 | — | — | 1 | 9.40 |
| CHEMBL381623 | — | — | 1 | 9.10 |
| CHEMBL200171 | — | — | 1 | 9.10 |
| CHEMBL200319 | — | — | 1 | 8.89 |
| CHEMBL203249 | — | — | 1 | 8.70 |
| CHEMBL200693 | — | — | 1 | 8.70 |
| CHEMBL382213 | — | — | 1 | 8.49 |
| CHEMBL200432 | — | — | 1 | 8.49 |
| CHEMBL1382 | TOLTERODINE | 4.0 | 1 | 8.40 |
| CHEMBL427013 | — | — | 1 | 8.40 |
| CHEMBL383389 | — | — | 1 | 8.30 |
| CHEMBL201933 | — | — | 1 | 8.30 |
| CHEMBL200957 | — | — | 1 | 7.89 |
| CHEMBL1231 | OXYBUTYNIN | 4.0 | 1 | 7.80 |
| CHEMBL371734 | — | — | 1 | 7.70 |
| CHEMBL381878 | — | — | 1 | 7.70 |
| CHEMBL200416 | — | — | 1 | 7.60 |
| CHEMBL199821 | — | — | 1 | 7.40 |
| CHEMBL383248 | — | — | 1 | 7.40 |
| CHEMBL1346 | DARIFENACIN | 4.0 | 1 | 7.30 |
| CHEMBL380583 | — | — | 1 | 7.30 |
| CHEMBL370862 | — | — | 1 | 7.30 |
| CHEMBL372566 | — | — | 1 | 7.30 |
| CHEMBL200210 | — | — | 1 | 7.10 |
| CHEMBL381469 | — | — | 1 | 7.00 |
| CHEMBL199981 | — | — | 1 | 6.90 |
| CHEMBL373256 | — | — | 1 | 6.60 |
| CHEMBL200208 | — | — | 1 | 6.60 |
| CHEMBL381020 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370232 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL200401 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL381623 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL200171 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL200319 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL203249 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL200693 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL382213 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL200432 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL1382 | TOLTERODINE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL427013 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL383389 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL201933 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL200957 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1231 | OXYBUTYNIN | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL381878 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL371734 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL200416 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL199821 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL383248 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL1346 | DARIFENACIN | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL380583 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL370862 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL372566 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL200210 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL381469 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL199981 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL373256 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL200208 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL381020 | — | Ki | = | 316.0 | nM | 6.50 |
| CHEMBL200209 | — | Ki | = | 501.0 | nM | 6.30 |
| CHEMBL200566 | — | Ki | = | 631.0 | nM | 6.20 |
| CHEMBL197973 | — | Ki | = | 3161.0 | nM | 5.50 |