Compound Detail
CHEMBL200666
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Basic Information
| ChEMBL ID | CHEMBL200666 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GUOMINFEASCICM-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
188.2
MW (Da)
2.64
ALogP
2
HBA
1
HBD
50.4
PSA (Ų)
0.79
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 4.79
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Methionine aminopeptidase CHEMBL3423 | IC50 | 4.79 | 4.79 | 16300.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.43 | 4.43 | 37000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Methionine aminopeptidase | IC50 | = | 16300.0 | nM | 4.79 | Inhibitory activity against Mn(II) form of Escherichia coli MetAP | 16219464 |
| Unchecked | IC50 | = | 37000.0 | nM | 4.43 | Inhibition of Rickettsia prowazekii str. Madrid E N-terminal His-tagged methioni... | 28089350 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16219464 | 10.1016/j.bmcl.2005.09.019 | Methionine aminopeptidase | 4 |
| 28089350 | 10.1016/j.bmc.2016.11.013 | Unchecked | 1 |
| 29940465 | 10.1016/j.ejmech.2018.06.033 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine