Compound Detail
CHEMBL2010876
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CC(C)Cn1c2ccc(Nc3nccc(C(F)(F)F)n3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3
Basic Information
| ChEMBL ID | CHEMBL2010876 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MHDAGXYQIWJNMU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
545.6
MW (Da)
5.75
ALogP
7
HBA
2
HBD
89.7
PSA (Ų)
0.30
QED
2
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.57 | 6.57 | 271.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 271.0 | nM | 6.57 | Inhibition of human recombinant VEGF-R2 expressed in baculovirus expression syst... | 22148921 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22148921 | 10.1021/jm201449n | Vascular endothelial growth factor receptor 2 | 2 |
| 22148921 | 10.1021/jm201449n | Angiopoietin-1 receptor | 1 |
Data from ChEMBL 36 via Core Engine