Compound Detail
CHEMBL2023159
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Basic Information
| ChEMBL ID | CHEMBL2023159 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DXROFJODNNFSMZ-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
317.4
MW (Da)
4.11
ALogP
2
HBA
2
HBD
54.0
PSA (Ų)
0.74
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rho-associated protein kinase 1 CHEMBL3231 | IC50 | 5.58 | 5.58 | 2610.0 | 2 |
| Rho-associated protein kinase 2 CHEMBL2973 | IC50 | 4.7 | 4.7 | 19800.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rho-associated protein kinase 1 | IC50 | = | 2610.0 | nM | 5.58 | Inhibition of human His-puritin-tagged ROCK1 expressed in Sf9 cells after 1 hr b... | 22272748 |
| Rho-associated protein kinase 1 | IC50 | = | 2610.0 | nM | 5.58 | FRET-Based Enzyme-Coupled Assay: A robust FRET-based, enzyme-coupled assay forma... | - |
| Rho-associated protein kinase 2 | IC50 | = | 19800.0 | nM | 4.7 | Inhibition of ROCK2 after 1 hr by FRET-based enzyme-coupled assay | 22272748 |
| Rho-associated protein kinase 2 | IC50 | = | 19800.0 | nM | 4.7 | FRET-Based Enzyme-Coupled Assay: A robust FRET-based, enzyme-coupled assay forma... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22272748 | 10.1021/jm201289r | Rho-associated protein kinase 1 | 1 |
| 22272748 | 10.1021/jm201289r | Unchecked | 1 |
| 22272748 | 10.1021/jm201289r | Rho-associated protein kinase 2 | 1 |
Data from ChEMBL 36 via Core Engine