Compound Detail
CHEMBL2024022
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Cc1nc(SCC(=O)[C@@]2(O)CC[C@H]3[C@@H]4CCC5=CC(=O)CC[C@]5(C)[C@H]4[C@@H](O)C[C@@]32C)sc1C
Basic Information
| ChEMBL ID | CHEMBL2024022 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OWZZHTDHOMLCGR-OKKNSTDLSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
489.7
MW (Da)
4.65
ALogP
7
HBA
2
HBD
87.5
PSA (Ų)
0.60
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | IC50 | 8.37 | 8.015 | 4.3 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | IC50 | = | 4.3 | nM | 8.37 | Inhibition of human glucocorticoid receptor | 22465636 |
| Glucocorticoid receptor | IC50 | = | 21.9 | nM | 7.66 | Transrepression activity at glucocorticoid receptor in human H292 cells assessed... | 22465636 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22465636 | 10.1016/j.bmcl.2012.03.015 | Glucocorticoid receptor | 4 |
Data from ChEMBL 36 via Core Engine