Compound Detail
CHEMBL2024347
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Basic Information
| ChEMBL ID | CHEMBL2024347 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LNTUICABIFIINZ-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
400.3
MW (Da)
5.21
ALogP
5
HBA
0
HBD
47.3
PSA (Ų)
0.47
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 5.3 | 4.9 | 5000.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 5000.0 | nM | 5.3 | Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mi... | 24900264 |
| Mitogen-activated protein kinase 14 | IC50 | = | 20000.0 | nM | 4.7 | Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1be... | 24900264 |
| Mitogen-activated protein kinase 14 | IC50 | = | 20000.0 | nM | 4.7 | Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFal... | 24900264 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900264 | 10.1021/ml2001455 | Mitogen-activated protein kinase 14 | 3 |
Data from ChEMBL 36 via Core Engine