Compound Detail
CHEMBL2029976
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Basic Information
| ChEMBL ID | CHEMBL2029976 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CQZWNBYMMHYOGC-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
483.5
MW (Da)
5.74
ALogP
8
HBA
2
HBD
120.6
PSA (Ų)
0.30
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.15
Kd 1 meas. best 5.84
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase B-raf CHEMBL5145 | Kd | 5.84 | 5.84 | 1454.0 | 1 |
| A-375 CHEMBL613859 | IC50 | 5.15 | 5.15 | 7069.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase B-raf | Kd | = | 1454.0 | nM | 5.84 | Inhibition of BRAF V600E mutant in human HEK293 cells after 1 hr by competition ... | 22168626 |
| A-375 | IC50 | = | 7069.0 | nM | 5.15 | Cytotoxicity against human A375 cells expressing BRAF V600E mutant after 72 hrs ... | 22168626 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22168626 | 10.1021/jm2009925 | Serine/threonine-protein kinase B-raf | 2 |
| 22168626 | 10.1021/jm2009925 | A-375 | 1 |
Data from ChEMBL 36 via Core Engine