Compound Detail
CHEMBL2031675
BLAPSIN A Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL2031675 |
| Name | BLAPSIN A |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DXMUHVKMWHWKJE-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
304.3
MW (Da)
1.84
ALogP
6
HBA
4
HBD
107.2
PSA (Ų)
0.50
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 14-3-3 protein gamma CHEMBL1293296 | IC50 | 5.7 | 5.37 | 2000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 14-3-3 protein gamma | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of recombinant GST-tagged 14-3-3gamma interaction with TMR-pS259-Raf ... | 22578460 |
| 14-3-3 protein gamma | IC50 | = | 9200.0 | nM | 5.04 | Inhibition of recombinant GST-tagged 14-3-3gamma interaction with PRAS40 in Cos7... | 22578460 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22578460 | 10.1016/j.bmcl.2012.04.027 | 14-3-3 protein gamma | 2 |
| 31954881 | 10.1016/j.ejmech.2020.112048 | Influenza A virus | 1 |
| 31954881 | 10.1016/j.ejmech.2020.112048 | MDCK | 1 |
Data from ChEMBL 36 via Core Engine