14-3-3 protein gamma · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P61981. Use UniProt P61981 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P61981 as the stable identity anchor, then attach disease evidence before program review.
14-3-3 protein gamma
Review this target as 14-3-3 protein gamma, mapped to UniProt P61981. Sequence length is 247 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 14-3-3 protein gamma as ChEMBL target CHEMBL1293296, mapped to UniProt P61981. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether 14-3-3 protein gamma is the right protein anchor across sources, using UniProt P61981 as the stable mapping.
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| Preferred Name | 14-3-3 protein gamma |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P61981 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 14-3-3 protein gamma |
| UniProt Accession | P61981 |
| Component Type | Protein |
| Sequence Length | 247 aa |
14-3-3 protein gamma
Review this target as 14-3-3 protein gamma, mapped to UniProt P61981. Sequence length is 247 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3752910 | 8.36 | Kd | 4.41 | Preclinical |
| CHEMBL1232461 | 6.28 | IC50 | 530.0 | Clinical |
| CHEMBL5653589 | 6.17 | Kd | 668.77 | Preclinical |
| CHEMBL1502839 | 6.07 | IC50 | 852.7 | Preclinical |
| CHEMBL2031675 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL2031676 | 5.6 | IC50 | 2500.0 | Preclinical |
| CHEMBL1598223 | 5.5 | IC50 | 3147.3 | Preclinical |
| CHEMBL1385512 | 5.3 | IC50 | 5022.5 | Preclinical |
| CHEMBL2003304 | 5.14 | IC50 | 7294.5 | Preclinical |
| CHEMBL1544329 | 5.05 | IC50 | 8916.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 8 | 5 | 6.4 |
| cell-based format | 3 | 3 | 4.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 14 | 4.9 |