Compound Detail
CHEMBL2031676
BLAPSIN B Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2031676 |
| Name | BLAPSIN B |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OLEHILHKGHOVLE-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
274.3
MW (Da)
2.17
ALogP
5
HBA
4
HBD
90.2
PSA (Ų)
0.60
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 14-3-3 protein gamma CHEMBL1293296 | IC50 | 5.6 | 5.3 | 2500.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 14-3-3 protein gamma | IC50 | = | 2500.0 | nM | 5.6 | Inhibition of recombinant GST-tagged 14-3-3gamma interaction with TMR-pS259-Raf ... | 22578460 |
| 14-3-3 protein gamma | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of recombinant GST-tagged 14-3-3gamma interaction with PRAS40 in Cos7... | 22578460 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22578460 | 10.1016/j.bmcl.2012.04.027 | 14-3-3 protein gamma | 2 |
Data from ChEMBL 36 via Core Engine