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Compound Detail

CHEMBL1598223

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CC1=CC(C#N)(C#N)C(C#N)(C#N)C(c2ccccc2)N1

Basic Information

ChEMBL ID CHEMBL1598223
Phase Preclinical
Structure Type MOL
InChI Key FEGNGDZLEHJWID-UHFFFAOYSA-N
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

273.3
MW (Da)
2.30
ALogP
5
HBA
1
HBD
107.2
PSA (Ų)
0.84
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H11N5
MW 273.30
Aromatic Rings 1
Heavy Atoms 21
NP-Likeness 0.18

Activity Summary

EC50 2 meas. best 5.61
IC50 2 meas. best 5.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Zinc finger protein mex-5
CHEMBL1293319
EC50 5.61 5.61 2456.0 1
14-3-3 protein gamma
CHEMBL1293296
IC50 5.5 5.5 3147.3 1
RNA-binding protein pos-1
CHEMBL1293304
EC50 5.5 5.5 3144.0 1
Heat shock protein HSP90
CHEMBL2095165
IC50 5.13 5.13 7382.3 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine