Compound Detail
CHEMBL205645
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Basic Information
| ChEMBL ID | CHEMBL205645 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UBTXPQLEIYAULK-CWDCEQMOSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
281.4
MW (Da)
2.78
ALogP
4
HBA
1
HBD
47.0
PSA (Ų)
0.92
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | IC50 | 4.62 | 4.62 | 23910.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 23910.0 | nM | 4.62 | Inhibition of Akt1 using 10 uM ATP | 16403626 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16403626 | 10.1016/j.bmcl.2005.12.017 | RAC-alpha serine/threonine-protein kinase | 1 |
Data from ChEMBL 36 via Core Engine