Compound Detail
CHEMBL205820
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Basic Information
| ChEMBL ID | CHEMBL205820 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KVYKDXMRLMPSGQ-NSCUHMNNSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
255.3
MW (Da)
2.37
ALogP
4
HBA
1
HBD
61.0
PSA (Ų)
0.80
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.83
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | IC50 | 4.83 | 4.83 | 14710.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 14710.0 | nM | 4.83 | Inhibition of Akt1 using 10 uM ATP | 16403626 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16403626 | 10.1016/j.bmcl.2005.12.017 | RAC-alpha serine/threonine-protein kinase | 1 |
Data from ChEMBL 36 via Core Engine