Compound Detail
CHEMBL2059582
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COC[C@@H]1CCCN1CCCCCCN1[C@@H]2CC[C@H]1C[C@@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2
Basic Information
| ChEMBL ID | CHEMBL2059582 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VOPUYPPXVMIQOA-QYOOZWMWSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
509.7
MW (Da)
5.01
ALogP
6
HBA
1
HBD
62.6
PSA (Ų)
0.41
QED
2
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 9.1
Ki 1 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 CHEMBL1875 | EC50 | 9.1 | 9.1 | 0.8 | 1 |
| 5-hydroxytryptamine receptor 4 CHEMBL1875 | Ki | 9.1 | 9.1 | 0.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | EC50 | = | 0.7943 | nM | 9.1 | Agonist activity at human 5HT4C receptor expressed at 100 fold physiological-lev... | 22683222 |
| 5-hydroxytryptamine receptor 4 | Ki | = | 0.7943 | nM | 9.1 | Displacement of [3H]GR113808 from human recombinant 5HT4C receptor expressed in ... | 22683222 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22683222 | 10.1016/j.bmcl.2012.05.034 | 5-hydroxytryptamine receptor 4 | 3 |
| 22683222 | 10.1016/j.bmcl.2012.05.034 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine