Compound Detail
CHEMBL206708
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N[C@H](COc1cncc(/C=C/c2ccnc(-n3ccc4ccccc43)c2)c1)Cc1c[nH]c2ccccc12
Basic Information
| ChEMBL ID | CHEMBL206708 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HJGRQCRBHSDOIH-OGJPMFGRSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
485.6
MW (Da)
6.02
ALogP
5
HBA
2
HBD
81.8
PSA (Ų)
0.28
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | IC50 | 5.48 | 5.48 | 3340.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 3340.0 | nM | 5.48 | Inhibition of Akt1 using 10 uM ATP | 16403626 |
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 3340.0 | nM | 5.48 | Inhibition of Akt | 19497644 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16403626 | 10.1016/j.bmcl.2005.12.017 | RAC-alpha serine/threonine-protein kinase | 1 |
| 19497644 | 10.1016/j.ejmech.2009.04.050 | RAC-alpha serine/threonine-protein kinase | 1 |
Data from ChEMBL 36 via Core Engine