Compound Detail
CHEMBL2069506
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
[O-][S+]1CCC(C2N[C@@H](c3nc(-c4ccccc4)c[nH]3)Cc3c2[nH]c2ccccc32)CC1
Basic Information
| ChEMBL ID | CHEMBL2069506 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DFCUYQJNXQZEGT-HYMMBLMBSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
430.6
MW (Da)
4.64
ALogP
3
HBA
3
HBD
79.6
PSA (Ų)
0.41
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 3 CHEMBL2028 | IC50 | 7.68 | 7.095 | 21.0 | 4 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 3 | IC50 | = | 21.0 | nM | 7.68 | Displacement of [125I]SS-14 from human SST3 receptor expressed in CHO cells afte... | 24900466 |
| Somatostatin receptor type 3 | IC50 | = | 24.0 | nM | 7.62 | Antagonist activity at human SST3 receptor expressed in CHO cells assessed as in... | 24900466 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 100.0 | nM | 7.0 | Displacement of [35S]MK499 from human Erg expressed in HEK293 cells after 60 min... | 24900466 |
| Somatostatin receptor type 3 | IC50 | = | 220.0 | nM | 6.66 | Displacement of [125I]SS-14 from human SST3 receptor expressed in CHO cells afte... | 24900466 |
| Somatostatin receptor type 3 | IC50 | = | 380.0 | nM | 6.42 | Antagonist activity at human SST3 receptor expressed in CHO cells assessed as in... | 24900466 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900466 | 10.1021/ml200272z | Somatostatin receptor type 3 | 4 |
| 24900466 | 10.1021/ml200272z | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine