Compound Detail
CHEMBL2074971
N-Norgallopamil Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL2074971 |
| Name | N-Norgallopamil |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JBERDSXBGRTWOG-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
470.6
MW (Da)
4.76
ALogP
7
HBA
1
HBD
82.0
PSA (Ų)
0.40
QED
0
Ro5 Violations
14
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| ATP-dependent translocase ABCB1 CHEMBL4302 | IC50 | 5.44 | 5.2733 | 3600.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| ATP-dependent translocase ABCB1 | IC50 | = | 3600.0 | nM | 5.44 | TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells | 11716514 |
| ATP-dependent translocase ABCB1 | IC50 | = | 4900.0 | nM | 5.31 | TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells | 11716514 |
| ATP-dependent translocase ABCB1 | IC50 | = | 8600.0 | nM | 5.07 | TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells | 11716514 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11716514 | 10.1006/bbrc.2001.6000 | ATP-dependent translocase ABCB1 | 3 |
Data from ChEMBL 36 via Core Engine