Assay Detail
Functional
CHEMBL2076218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | NIH-3T3-G185 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.08 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL772 | RESERPINE | 4.0 | 1 | 6.30 |
| CHEMBL1292 | CLOFAZIMINE | 4.0 | 1 | 6.22 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 5.85 |
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | 5.75 |
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 5.50 |
| CHEMBL2074971 | N-Norgallopamil | — | 1 | 5.44 |
| CHEMBL1741 | CLARITHROMYCIN | 4.0 | 1 | 5.42 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 5.38 |
| CHEMBL723 | CARVEDILOL | 4.0 | 1 | 5.34 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.25 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 5.19 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 5.19 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 5.14 |
| CHEMBL50588 | EMETINE | 4.0 | 1 | 5.04 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 4.75 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 4.73 |
| CHEMBL170 | QUININE | 4.0 | 1 | 4.65 |
| CHEMBL932 | DIPYRIDAMOLE | 4.0 | 1 | 4.64 |
| CHEMBL1480 | FELODIPINE | 4.0 | 1 | 4.58 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 4.27 |
| CHEMBL564085 | TROLEANDOMYCIN | 4.0 | 1 | 4.17 |
| CHEMBL52606 | COLFORSIN | 2.0 | 1 | 4.10 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 4.02 |
| CHEMBL1182234 | TETRAPHENYLPHOSPHONIUM | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL772 | RESERPINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL17157 | TERFENADINE | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1484 | NICARDIPINE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2074971 | N-Norgallopamil | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1741 | CLARITHROMYCIN | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL723 | CARVEDILOL | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL422 | TRIFLUOPERAZINE | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL50588 | EMETINE | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL1294 | QUINIDINE | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL170 | QUININE | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL932 | DIPYRIDAMOLE | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL1480 | FELODIPINE | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL564085 | TROLEANDOMYCIN | IC50 | = | 68300.0 | nM | 4.17 |
| CHEMBL52606 | COLFORSIN | IC50 | = | 80200.0 | nM | 4.10 |
| CHEMBL103 | PROGESTERONE | IC50 | = | 96200.0 | nM | 4.02 |
| CHEMBL1182234 | TETRAPHENYLPHOSPHONIUM | IC50 | = | 490000.0 | nM | - |