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Compound Detail

CHEMBL208185

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CCOCCOc1ccc(OC[C@@H](O)CNCCc2ccc(OC)c(OC)c2)cc1

Basic Information

ChEMBL ID CHEMBL208185
Phase Preclinical
Structure Type MOL
InChI Key NLOWRHHPLNNIIQ-IBGZPJMESA-N
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

419.5
MW (Da)
2.69
ALogP
7
HBA
2
HBD
78.4
PSA (Ų)
0.43
QED
0
Ro5 Violations
15
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H33NO6
MW 419.52
Aromatic Rings 2
Heavy Atoms 30
NP-Likeness -0.54

Activity Summary

Ki 5 meas. best 7.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL3252
Ki 7.3 6.48 50.1 5

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16759089 10.1021/jm050624l Beta-1 adrenergic receptor 5

Data from ChEMBL 36 via Core Engine