Compound Detail
CHEMBL2087566
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Basic Information
| ChEMBL ID | CHEMBL2087566 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WPDJIWKWYHDKLS-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
479.6
MW (Da)
4.72
ALogP
7
HBA
1
HBD
68.5
PSA (Ų)
0.45
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | IC50 | = | 200.0 | nM | 6.7 | Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells aft... | 22587443 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22587443 | 10.1021/jm300259r | Corticotropin-releasing factor receptor 1 | 1 |
| 22587443 | 10.1021/jm300259r | Liver microsomes | 1 |
| 22587443 | 10.1021/jm300259r | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine