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Compound Detail

CHEMBL2092793

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CCCCCCSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=S)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1

Basic Information

ChEMBL ID CHEMBL2092793
Phase Preclinical
Structure Type MOL
InChI Key ZVZNYNIFYBLKFQ-SMUXNDDWSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

639.5
MW (Da)
1.16
ALogP
15
HBA
7
HBD
262.1
PSA (Ų)
0.07
QED
3
Ro5 Violations
14
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H28N5O12P3S2
MW 639.48
Aromatic Rings 2
Heavy Atoms 38
NP-Likeness 0.54

Activity Summary

EC50 2 meas. best 7.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
P2Y purinoceptor 1
CHEMBL5720
EC50 7.77 7.725 17.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10479295 10.1021/jm990158y P2Y purinoceptor 1 2

Data from ChEMBL 36 via Core Engine