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Assay Detail

CHEMBL759182

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonistic activity for P2Y purinoceptor 1 of turkey erythrocyte membranes
12
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Meleagris gallopavo
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

P2Y purinoceptor 1 (CHEMBL5720)
Type SINGLE PROTEIN
Organism Meleagris gallopavo

Publication

2-thioether 5'-O-(1-thiotriphosphate)adenosine derivatives as new insulin secretagogues acting through P2Y-Receptors.
Fischer B, Chulkin A, Boyer JL, Harden KT, Gendron FP, Beaudoin AR, Chapal J, Hillaire-Buys D, Petit P.
J Med Chem (1999) 42 : 3636 -3646
PubMed 10479295 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 6.50 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL611285 1 8.00
CHEMBL608639 1 7.92
CHEMBL2092793 2 7.77
CHEMBL130094 1 7.22
CHEMBL2092794 2 6.29
CHEMBL3351026 1 5.63
CHEMBL607771 1 5.55
CHEMBL610985 1 5.52
CHEMBL611286 1 5.20
CHEMBL14249 ADENOSINE TRIPHOSPHATE 2.0 1 5.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL611285 EC50 = 10.0 nM 8.00
CHEMBL608639 EC50 = 12.0 nM 7.92
CHEMBL2092793 EC50 = 17.0 nM 7.77
CHEMBL2092793 EC50 = 21.0 nM 7.68
CHEMBL130094 EC50 = 60.0 nM 7.22
CHEMBL2092794 EC50 = 510.0 nM 6.29
CHEMBL2092794 EC50 = 890.0 nM 6.05
CHEMBL3351026 EC50 = 2360.0 nM 5.63
CHEMBL607771 EC50 = 2790.0 nM 5.55
CHEMBL610985 EC50 = 3000.0 nM 5.52
CHEMBL611286 EC50 = 6275.0 nM 5.20
CHEMBL14249 ADENOSINE TRIPHOSPHATE EC50 = 6353.0 nM 5.20