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Compound Detail

CHEMBL607771

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CCCCCCSc1nc(N)c2ncn(C3O[C@H](COP([O-])([O-])=S)[C@@H](O)[C@H]3O)c2n1.[Na+].[Na+]

Basic Information

ChEMBL ID CHEMBL607771
Phase Preclinical
Structure Type MOL
InChI Key KLZDSYVLTCMEKG-BDXCFMAUSA-L
Parent Compound CHEMBL1208524
Active Moiety CHEMBL1208524
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

479.5
MW (Da)
0.93
ALogP
11
HBA
5
HBD
169.0
PSA (Ų)
0.14
QED
1
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H24N5Na2O6PS2
MW 523.49
Aromatic Rings 2
Heavy Atoms 30
NP-Likeness 0.43

Activity Summary

EC50 1 meas. best 5.55

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
P2Y purinoceptor 1
CHEMBL5720
EC50 5.55 5.55 2790.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
P2Y purinoceptor 1 EC50 = 2790.0 nM 5.55 Agonistic activity for P2Y purinoceptor 1 of turkey erythrocyte membranes 10479295

Literature References

PubMed DOI Target Context # Activities
10479295 10.1021/jm990158y P2Y purinoceptor 1 1

Data from ChEMBL 36 via Core Engine