Compound Detail
CHEMBL209645
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Basic Information
| ChEMBL ID | CHEMBL209645 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MBYKQBGSIZDRKG-NMWGTECJSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
356.4
MW (Da)
3.17
ALogP
5
HBA
0
HBD
41.0
PSA (Ų)
0.56
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(4) dopamine receptor CHEMBL219 | EC50 | 7.47 | 7.47 | 33.5 | 1 |
| D(2) dopamine receptor CHEMBL217 | EC50 | 6.44 | 6.44 | 366.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(4) dopamine receptor | EC50 | = | 33.5 | nM | 7.47 | Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR a... | 16913699 |
| D(2) dopamine receptor | EC50 | = | 366.0 | nM | 6.44 | Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by F... | 16913699 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16913699 | 10.1021/jm060279f | D(2) dopamine receptor | 3 |
| 16913699 | 10.1021/jm060279f | D(4) dopamine receptor | 2 |
Data from ChEMBL 36 via Core Engine