Assay Detail
Functional
CHEMBL866786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay
106
Total Activities
106
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 106 | 6.44 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209645 | — | — | 1 | 6.44 |
| CHEMBL213106 | — | — | 1 | - |
| CHEMBL212804 | — | — | 1 | - |
| CHEMBL211972 | — | — | 1 | - |
| CHEMBL438961 | — | — | 1 | - |
| CHEMBL215670 | — | — | 1 | - |
| CHEMBL376955 | — | — | 1 | - |
| CHEMBL213700 | — | — | 1 | - |
| CHEMBL376639 | — | — | 1 | - |
| CHEMBL261957 | — | — | 1 | - |
| CHEMBL212831 | — | — | 1 | - |
| CHEMBL213572 | — | — | 1 | - |
| CHEMBL212782 | — | — | 1 | - |
| CHEMBL385826 | — | — | 1 | - |
| CHEMBL377050 | — | — | 1 | - |
| CHEMBL212075 | — | — | 1 | - |
| CHEMBL214343 | — | — | 1 | - |
| CHEMBL211985 | — | — | 1 | - |
| CHEMBL214190 | — | — | 1 | - |
| CHEMBL384529 | — | — | 1 | - |
| CHEMBL212902 | — | — | 1 | - |
| CHEMBL212298 | — | — | 1 | - |
| CHEMBL212847 | — | — | 1 | - |
| CHEMBL212189 | — | — | 1 | - |
| CHEMBL212188 | — | — | 1 | - |
| CHEMBL214440 | — | — | 1 | - |
| CHEMBL215849 | — | — | 1 | - |
| CHEMBL385230 | — | — | 1 | - |
| CHEMBL214954 | — | — | 1 | - |
| CHEMBL385350 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209645 | — | EC50 | = | 366.0 | nM | 6.44 |
| CHEMBL212288 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL379546 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL211463 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL213004 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL211623 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL213164 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL214314 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL213518 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL45244 | PD-168,077 | EC50 | > | 10000.0 | nM | - |
| CHEMBL212901 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL378302 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL211360 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL213097 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL212028 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL215723 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL213828 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL212969 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL212595 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL378427 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL212891 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL209447 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL211415 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL213208 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL427048 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL212490 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL378576 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL209472 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL212235 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL212236 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL377585 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL212872 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL211732 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL215705 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL377794 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL212393 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL209759 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL211829 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL437532 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL211902 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL378324 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL213558 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL215569 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL215450 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL212444 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL215678 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL212291 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL212292 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL214197 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL210101 | — | EC50 | > | 10000.0 | nM | - |