Compound Detail
CHEMBL2104415
MOXIDECTIN 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
CO/N=C1\C[C@]2(C[C@@H]3C[C@@H](C/C=C(\C)C[C@@H](C)/C=C/C=C4\CO[C@@H]5[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]45O)O2)O[C@H](/C(C)=C/C(C)C)[C@H]1C
Basic Information
| ChEMBL ID | CHEMBL2104415 |
| Name | MOXIDECTIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | YZBLFMPOMVTDJY-LSGXYNIPSA-N |
| Therapeutic | ✓ Yes |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
7
Publications
9
Known Names
5
Indications
1
Mechanisms
Molecular Properties
639.8
MW (Da)
5.73
ALogP
9
HBA
2
HBD
116.0
PSA (Ų)
0.23
QED
2
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2018 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Unknown | - | - | ✓ | ✓ |
Indications
Helminthiasis Onchocerciasis Elephantiasis, Filarial Strongyloidiasis Infections
ATC Classification
P02CX03
moxidectin
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ANTHELMINTICS
Activity Summary
IC50 2 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Caenorhabditis elegans CHEMBL613135 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
| Haemonchus contortus CHEMBL613144 | IC50 | 5.52 | 5.52 | 3000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | IC50 | = | 100.0 | nM | 7.0 | Anthelmintic activity against Caenorhabditis elegans N2 Bristol assessed as redu... | 38134663 |
| Haemonchus contortus | IC50 | = | 3000.0 | nM | 5.52 | Anthelmintic activity against third stage larvae of Haemonchus contortus assesse... | 36799121 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36799121 | 10.1021/acs.jnatprod.2c01041 | Haemonchus contortus | 4 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 38134663 | 10.1016/j.bmc.2023.117540 | Caenorhabditis elegans | 1 |
Data from ChEMBL 36 via Core Engine