Assay Detail
Functional
CHEMBL5255113
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Anthelmintic activity against third stage larvae of Haemonchus contortus assessed as reduction in larval motility measured at 168 hrs by microscope based analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Haemonchus contortus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Using a Bioactive <i>Eremophila</i>-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.55 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256563 | MONEPANTEL | 1.0 | 1 | 6.70 |
| CHEMBL5267329 | — | — | 1 | 6.40 |
| CHEMBL5289445 | — | — | 1 | 6.10 |
| CHEMBL5288717 | — | — | 1 | 5.80 |
| CHEMBL5283318 | — | — | 1 | 5.75 |
| CHEMBL2104415 | MOXIDECTIN | 4.0 | 1 | 5.52 |
| CHEMBL4084409 | — | — | 1 | 5.44 |
| CHEMBL5271594 | — | — | 1 | 5.31 |
| CHEMBL5281384 | — | — | 1 | 5.21 |
| CHEMBL5289595 | — | — | 1 | 5.19 |
| CHEMBL5267153 | — | — | 1 | 5.15 |
| CHEMBL5275076 | — | — | 1 | 5.05 |
| CHEMBL5288678 | — | — | 1 | 4.50 |
| CHEMBL5267129 | — | — | 1 | - |
| CHEMBL5289227 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256563 | MONEPANTEL | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5267329 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5289445 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5288717 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5283318 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2104415 | MOXIDECTIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4084409 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5271594 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5281384 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5289595 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL5267153 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL5275076 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5288678 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL5267129 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5289227 | — | IC50 | > | 50000.0 | nM | - |