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Compound Detail

CHEMBL5271594

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COC(=O)c1cc2c(c(OC)c1OC)[C@H](C)C[C@@H](O)[C@H]2[C@@H](C)CCC=C(C)C

Basic Information

ChEMBL ID CHEMBL5271594
Phase Preclinical
Structure Type MOL
InChI Key DFSZRMLMJHCTHC-SFUIVIKGSA-N
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

390.5
MW (Da)
4.82
ALogP
5
HBA
1
HBD
65.0
PSA (Ų)
0.53
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H34O5
MW 390.52
Aromatic Rings 1
Heavy Atoms 28
NP-Likeness 1.69

Activity Summary

EC50 2 meas. best 4.42
IC50 2 meas. best 5.31

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Haemonchus contortus
CHEMBL613144
IC50 5.31 5.09 4900.0 2
Human immunodeficiency virus 1
CHEMBL378
EC50 4.42 4.42 38300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
36799121 10.1021/acs.jnatprod.2c01041 Haemonchus contortus 7
36799121 10.1021/acs.jnatprod.2c01041 Human immunodeficiency virus 1 3
36799121 10.1021/acs.jnatprod.2c01041 Plasmodium falciparum 2
36799121 10.1021/acs.jnatprod.2c01041 HEK293 1

Data from ChEMBL 36 via Core Engine