Compound Detail
CHEMBL2104987
TEDUGLUTIDE 💊 Approved Drug
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💊 Approved Drug
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC
Basic Information
| ChEMBL ID | CHEMBL2104987 |
| Name | TEDUGLUTIDE |
| Phase | Approved |
| Structure Type | BOTH |
| InChI Key | CILIXQOJUNDIDU-ASQIGDHWSA-N |
| Therapeutic | ✓ Yes |
2
Targets
3
Activities
1
Assay Types
5
PK Parameters
8
Publications
9
Known Names
10
Indications
1
Mechanisms
Molecular Properties
3752.1
MW (Da)
Drug Information
| Molecule Type | Protein |
| First Approval | 2012 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Glucagon-like peptide 2 receptor agonist | AGONIST | Glucagon-like peptide 2 receptor | ✓ | ✓ |
Indications
Malabsorption Syndromes Short Bowel Syndrome Short Bowel Syndrome Crohn Disease HIV Infections Hyperlipidemias Malnutrition Kidney Diseases Liver Diseases Graft vs Host Disease
ATC Classification
A16AX08
teduglutide
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
Activity Summary
EC50 3 meas. best 11.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucagon-like peptide 2 receptor CHEMBL5844 | EC50 | 11.0 | 10.525 | 0.0 | 2 |
| Glucagon-like peptide 2 receptor CHEMBL3822349 | EC50 | 10.1 | 10.1 | 0.1 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 9.9 | mL.min-1.kg-1 | Rattus norvegicus |
| F | 88.0 | % | Homo sapiens |
| T1/2 | 3.0 | hr | Homo sapiens |
| T1/2 | 2.0 | hr | Homo sapiens |
| T1/2 | 1.3 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucagon-like peptide 2 receptor | EC50 | = | 0.01 | nM | 11.0 | Agonist activity at human GLP2 receptor expressed in HEK293 cells assessed as in... | - |
| Glucagon-like peptide 2 receptor | EC50 | = | 0.08 | nM | 10.1 | Agonist activity at rat GLP2R expressed in HEK293 cells after 5 hrs by luciferas... | 26986178 |
| Glucagon-like peptide 2 receptor | EC50 | = | 0.09 | nM | 10.05 | Agonist activity at human GLP2R expressed in HEK293 cells after 5 hrs by lucifer... | 26986178 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26986178 | 10.1021/acs.jmedchem.5b01909 | Glucagon-like peptide 2 receptor | 3 |
| 26986178 | 10.1021/acs.jmedchem.5b01909 | Rattus norvegicus | 2 |
| 38691890 | 10.1016/j.ejmech.2024.116456 | ADMET | 2 |
| 26986178 | 10.1021/acs.jmedchem.5b01909 | Glucagon-like peptide 1 receptor | 1 |
| 26986178 | 10.1021/acs.jmedchem.5b01909 | Unchecked | 1 |
| 26986178 | 10.1021/acs.jmedchem.5b01909 | Homo sapiens | 1 |
| 26986178 | 10.1021/acs.jmedchem.5b01909 | Plasma | 1 |
| 31577440 | 10.1021/acs.jmedchem.9b00835 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine