Compound Detail

CHEMBL2105209

MINAXOLONE

🧪 Phase II

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🧪 Phase II

CCO[C@H]1C[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2[C@H](N(C)C)C[C@]2(C)[C@@H](C(C)=O)CC[C@@H]32)C[C@@H]1O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL2105209
Name	MINAXOLONE
Phase	Phase II
Structure Type	MOL
InChI Key	NCGLTZSBTFVVAW-KNXRZYMVSA-N

Known Names

C.C.I. 12923 CCI-12923 Minaxolona Minaxolone

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

405.6

MW (Da)

4.15

ALogP

HBA

HBD

49.8

PSA (Å²)

0.76

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
Chirality	Single Enantiomer

Flags

Natural Product

USAN Stem	-olone
USAN Year	1979

Extended Properties

Molecular Formula	C25H43NO3
MW	405.62
Aromatic Rings	0
Heavy Atoms	29
NP-Likeness	1.90

Activity Summary

IC50 1 meas. best 7.15

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
GABA-A receptor; anion channel CHEMBL1907607	IC50	7.15	7.15	71.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
GABA-A receptor; anion channel	IC50	=	71.0	nM	7.15	The concentration required to inhibit 50% of binding of [35S]TBPS to Gamma-amino...	9171876

Literature References

PubMed	DOI	Target Context	# Activities
9171876	10.1021/jm960733n	Mus musculus	2
9171876	10.1021/jm960733n	GABA-A receptor; anion channel	1
9171876	10.1021/jm960733n	ADMET	1

Data from ChEMBL 36 via Core Engine