Compound Detail
CHEMBL2106789
NANAFROCIN 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL2106789 |
| Name | NANAFROCIN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | ZCJHPTKRISJQTN-JGVFFNPUSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
14
Publications
4
Known Names
Molecular Properties
302.3
MW (Da)
1.72
ALogP
5
HBA
2
HBD
100.9
PSA (Ų)
0.86
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 4 meas. best 6.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| DNA (cytosine-5)-methyltransferase 3B CHEMBL6095 | IC50 | 6.3 | 6.14 | 500.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| DNA (cytosine-5)-methyltransferase 3B | IC50 | = | 500.0 | nM | 6.3 | Inhibition of His6-tagged human recombinant DNMT3b expressed in insect Sf9 cells... | 25406944 |
| DNA (cytosine-5)-methyltransferase 3B | IC50 | = | 500.0 | nM | 6.3 | Inhibition of human DNMT3B using [3H]-SAM | 32435413 |
| DNA (cytosine-5)-methyltransferase 3B | IC50 | = | 730.0 | nM | 6.14 | Inhibition of human recombinant DNMT3B expressed in baculovirus infected insect ... | 32435413 |
| DNA (cytosine-5)-methyltransferase 3B | IC50 | = | 1500.0 | nM | 5.82 | Inhibition of human recombinant DNMT3B expressed in baculovirus infected insect ... | 32435413 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32435413 | 10.1021/acsmedchemlett.0c00011 | DNA (cytosine-5)-methyltransferase 3B | 3 |
| 25406944 | 10.1021/jm500843d | DNA (cytosine-5)-methyltransferase 3B | 1 |
| 32435413 | 10.1021/acsmedchemlett.0c00011 | ADMET | 1 |
| 32435413 | 10.1021/acsmedchemlett.0c00011 | Vero | 1 |
| - | 10.6019/CHEMBL5724796 | Casein kinase I isoform delta | 1 |
| - | 10.6019/CHEMBL5724796 | Cyclin-dependent kinase 2 | 1 |
| - | 10.6019/CHEMBL5724796 | Glycogen synthase kinase-3 beta | 1 |
| - | 10.6019/CHEMBL5724796 | Mitogen-activated protein kinase 1 | 1 |
| - | 10.6019/CHEMBL5724796 | Aurora kinase A | 1 |
| - | 10.6019/CHEMBL5724796 | Tyrosine-protein kinase ABL1 | 1 |
| - | 10.6019/CHEMBL5724796 | Fibroblast growth factor receptor 2 | 1 |
| - | 10.6019/CHEMBL5724796 | Peregrin | 1 |
| - | 10.6019/CHEMBL5724796 | Transcription intermediary factor 1-alpha | 1 |
| - | 10.6019/CHEMBL5724796 | Bromodomain-containing protein 4 | 1 |
Data from ChEMBL 36 via Core Engine