Compound Detail
CHEMBL211112
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Basic Information
| ChEMBL ID | CHEMBL211112 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KSBRXTQOZDUEGL-JYRVWZFOSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
301.3
MW (Da)
3.28
ALogP
5
HBA
1
HBD
68.5
PSA (Ų)
0.88
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence in... | 25050878 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16789742 | 10.1021/jm0601598 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
| 25050878 | 10.1016/j.ejmech.2014.07.056 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
Data from ChEMBL 36 via Core Engine