Assay Detail
Binding
CHEMBL3366680
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensity using phosphorylated substrate
98
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 98 | 6.39 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393121 | — | — | 1 | 8.09 |
| CHEMBL246440 | — | — | 1 | 8.00 |
| CHEMBL241710 | — | — | 1 | 7.99 |
| CHEMBL392349 | — | — | 1 | 7.96 |
| CHEMBL394234 | — | — | 1 | 7.95 |
| CHEMBL246859 | — | — | 1 | 7.95 |
| CHEMBL394235 | — | — | 1 | 7.93 |
| CHEMBL246441 | — | — | 1 | 7.75 |
| CHEMBL392914 | — | — | 1 | 7.74 |
| CHEMBL246647 | — | — | 1 | 7.74 |
| CHEMBL211819 | — | — | 1 | 7.70 |
| CHEMBL241718 | — | — | 1 | 7.70 |
| CHEMBL211173 | — | — | 1 | 7.70 |
| CHEMBL429657 | — | — | 1 | 7.69 |
| CHEMBL246857 | — | — | 1 | 7.68 |
| CHEMBL398988 | — | — | 1 | 7.56 |
| CHEMBL3325884 | — | — | 1 | 7.54 |
| CHEMBL208652 | — | — | 1 | 7.52 |
| CHEMBL393276 | — | — | 1 | 7.52 |
| CHEMBL379156 | — | — | 1 | 7.48 |
| CHEMBL239374 | — | — | 1 | 7.43 |
| CHEMBL377175 | — | — | 1 | 7.43 |
| CHEMBL377104 | — | — | 1 | 7.41 |
| CHEMBL378999 | — | — | 1 | 7.40 |
| CHEMBL212119 | — | — | 1 | 7.37 |
| CHEMBL211768 | — | — | 1 | 7.25 |
| CHEMBL210991 | — | — | 1 | 7.10 |
| CHEMBL391998 | — | — | 1 | 7.01 |
| CHEMBL240623 | — | — | 1 | 6.99 |
| CHEMBL378528 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393121 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL246440 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL241710 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL392349 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL394234 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL246859 | — | IC50 | = | 11.22 | nM | 7.95 |
| CHEMBL394235 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL246441 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL392914 | — | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL246647 | — | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL211819 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL241718 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL211173 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL429657 | — | IC50 | = | 20.43 | nM | 7.69 |
| CHEMBL246857 | — | IC50 | = | 20.9 | nM | 7.68 |
| CHEMBL398988 | — | IC50 | = | 27.7 | nM | 7.56 |
| CHEMBL3325884 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL208652 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL393276 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL379156 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL239374 | — | IC50 | = | 37.3 | nM | 7.43 |
| CHEMBL377175 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL377104 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL378999 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL212119 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL211768 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL210991 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL391998 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL240623 | — | IC50 | = | 103.4 | nM | 6.99 |
| CHEMBL378528 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL240620 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL241708 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL246645 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL241713 | — | IC50 | = | 152.4 | nM | 6.82 |
| CHEMBL240621 | — | IC50 | = | 184.5 | nM | 6.73 |
| CHEMBL437688 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL211068 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL208662 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL438133 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL211759 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL208696 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL209194 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL377337 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL376984 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL211112 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL208866 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3326777 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL1213083 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL3326383 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL209409 | — | IC50 | = | 2600.0 | nM | 5.58 |