Compound Detail
CHEMBL3326383
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Basic Information
| ChEMBL ID | CHEMBL3326383 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ULJHRLXEOKBUDN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
434.9
MW (Da)
4.31
ALogP
7
HBA
1
HBD
89.3
PSA (Ų)
0.33
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | IC50 | 5.59 | 5.59 | 2540.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | IC50 | = | 2540.0 | nM | 5.59 | Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence in... | 25050878 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25050878 | 10.1016/j.ejmech.2014.07.056 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
Data from ChEMBL 36 via Core Engine