Compound Detail
CHEMBL246859
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Basic Information
| ChEMBL ID | CHEMBL246859 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UTIVWGUNTRBKGY-WQRHYEAKSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
426.5
MW (Da)
3.15
ALogP
6
HBA
1
HBD
67.9
PSA (Ų)
0.59
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | IC50 | 8.57 | 8.26 | 2.7 | 2 |
| Neutrophil CHEMBL613710 | IC50 | 6.43 | 6.43 | 375.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | IC50 | = | 2.66 | nM | 8.57 | Inhibition of PI3Kgamma assessed as inhibition of 32P-PIP3 formation | 17095227 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | IC50 | = | 11.22 | nM | 7.95 | Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence in... | 25050878 |
| Neutrophil | IC50 | = | 375.0 | nM | 6.43 | Inhibition of fMLP-induced superoxide production in human neutrophils | 17095227 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17095227 | 10.1016/j.bmcl.2006.10.080 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
| 17095227 | 10.1016/j.bmcl.2006.10.080 | Neutrophil | 1 |
| 17095227 | 10.1016/j.bmcl.2006.10.080 | Unchecked | 1 |
| 25050878 | 10.1016/j.ejmech.2014.07.056 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
Data from ChEMBL 36 via Core Engine