Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL2112044

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CN(C)CCN(C)CCNC(=O)[C@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1.O=C(O)C(F)(F)F

Basic Information

ChEMBL ID CHEMBL2112044
Phase Preclinical
Structure Type MOL
InChI Key RXCKNUNONUHMKM-LNLSOMNWSA-N
Parent Compound CHEMBL431562
Active Moiety CHEMBL431562
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

682.9
MW (Da)
2.94
ALogP
9
HBA
4
HBD
152.2
PSA (Ų)
0.11
QED
1
Ro5 Violations
15
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H43F3N8O7S2
MW 796.89
Aromatic Rings 3
Heavy Atoms 47
NP-Likeness -1.80

Activity Summary

Ki 1 meas. best 9.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
B2 bradykinin receptor
CHEMBL2501
Ki 9.22 9.22 0.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10715143 10.1021/jm991155o B2 bradykinin receptor 1

Data from ChEMBL 36 via Core Engine